Neuronal toll-like receptors and neuro-immunity in Parkinson’s disease, Alzheimer’s disease and stroke
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چکیده
Carmen D. Rietdijk1, Richard J. A. van Wezel2,3, Johan Garssen1,4, Aletta D. Kraneveld1 1Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, 3584 CG Utrecht, the Netherlands. 2Department of Biomedical Signals and Systems, MIRA, University of Twente, 7522 NB Enschede, the Netherlands. 3Department of Biophysics, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, 6500 GL Nijmegen, the Netherlands. 4Nutricia Research, Utrecht Science Park, 3584 CT Utrecht, the Netherlands. Toll-like receptors (TLRs) are part of the innate immune system and can initiate an immune response upon exposure to harmful microorganisms. Neuronal TLRs are considered to be part of an established framework of interactions between the immune system and the nervous system, the major sensing systems in mammals. TLRs in the nervous system and neuronal TLRs are suspected to be important during inflammation and neurodegenerative diseases. The aim of this review is to offer an overview of the current knowledge about TLRs in neurodegenerative pathologies, with a focus on Parkinson’s disease. More research focusing on the role of TLRs in health and disease of the nervous system is needed and remains to be explored.
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تاریخ انتشار 2016